Volume 70, Issue 3 (4 2012)                   Tehran Univ Med J 2012, 70(3): 150-155 | Back to browse issues page

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Minoo N N, Maryam Y, Hossein N, Adel G. Comparing carotid intima-media thickness in type 2 diabetes between patients with and without retinopathy. Tehran Univ Med J. 2012; 70 (3) :150-155
URL: http://tumj.tums.ac.ir/article-1-131-en.html
1- Department of Radiology, Rasoul Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Radiology, Rasoul Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , yousefimaryam77@yahoo.com
3- Department of Ophthalmology, Rasoul Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (19817 Views)

Background: Microangiopathy and macroangiopathy frequently coexist in type 2 diabetes mellitus (T2DM). Both types of the vascular complications share traditional risk factors but it is not clear whether the presence of microangiopathy, such as diabetic retinopathy, constitutes a predictor of atherosclerosis in carotid arteries in patients with the disease. In this study we looked for the association between diabetic retinopathy and intima-media thickness in carotid arteries of patients with T2DM.

Methods: In this case-control study we examined 100 consecutive patients with T2DM in Rasoul Akram Hospital in Tehran, Iran during 2009-2010. We assessed intima-media thickness of carotid arteries by ultrasonography. All patients underwent ophthalmo-logic examination.

Results: Diabetic retinopathy was found in 50 (50%) patients. Intima-media thickness was higher in patients with diabetic retinopathy than those without it (0.77±0.17 mm vs. 0.71±0.2 mm, respectively, P=0.041). Moreover, intima-media thickness was more prevalent in patients with proliferative diabetic retinopathy than patients with non-proliferative form of the disease (0.87±0.16 mm vs. 0.68±0.1 mm, respectively, P<0.001).

Conclusion: Diabetic retinopathy seems to be associated with increased intima-media thickness of carotid arteries in T2DM. It may be a common denominator of pathogene-sis of microvascular complications and atherosclerosis in T2DM. Evaluations of carotid arteries are to be done by non-invasive methods such as color Doppler sonography for screening and preventing prospective cereberovascular accidents in patients with diabetic retinopathy, especially proliferative retinopathy, in routine ophthalmological examination of patients with T2DM.

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