Volume 56, Issue 1 (30 1998)                   Tehran Univ Med J 1998, 56(1): 17-20 | Back to browse issues page

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Marzban H, Nasroallahzadeh B, Akbari M, Toobak M, Dehpoor A, Fazel A, et al . A Study of Anomaly Producing Effects of Disodium Hemiphtalate Glycyrrhetinic Acid on Skleton of Mice Embryo. Tehran Univ Med J. 1998; 56 (1) :17-20
URL: http://tumj.tums.ac.ir/article-1-1587-en.html
Abstract:   (5103 Views)
Disodium hemiphthalate Glycyrrhetinic acid (DHGA) possesses anti-inflammatory and analgestic activities. In our research, this agent was injected intraperitoneally to mice, according to the following schedule.
1) 25 mg/kg, 50mg/kg & 75mg/kg at 7th day of pregnancy.
2) 50 mg/kg & 75mg/kg at 8th day of pregnancy.
3) 50mg/kg & 75mg/kg at 9th day of pregnancy.
DHGA with doses of 50mg/kg and 75mg/kg at 7th, 8th and 9th day, delays the growth, decreases developing of ossification centers (specially in hand and foot middle phalanxes), decreases the number of caudal vertebrae of sacro-illiac joint and results in slight but important increases in fetus mortality.
Abbreviations
H & E=Haematoxylin & Eosin
CRL=Crown-Rump Length
BPD=Biparietal Diameter
W=Weight
ETS=Embryo Toxicity Score
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