Volume 53, Issue 1 (30 1995)                   Tehran Univ Med J 1995, 53(1): 14-18 | Back to browse issues page

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Daryani N, Samar G, Yalda A. Trial survey of alpha-interferon effect on 16 patients with chronic viral hepatitis. Tehran Univ Med J. 1995; 53 (1) :14-18
URL: http://tumj.tums.ac.ir/article-1-1699-en.html
Abstract:   (4592 Views)
Alpha-interferon therapy has been approved for treatment of chronic hepatitis C and B. Candidates for treatment are patients with well-compensated liver disease and histologic evidences of chronic hepatitis who have demonstrated abnormal aminotransferase levels for more than 6 months. From 30 patients with chronic hepatitis with diseases prolonged more than 6 months, we selected only 16 patients with necessary criteria for interferon therapy (10 patients with chronic HBV and with evidence of viral replication, and 6 patients with chronic HCV). Dose of interferon used for hepatitis B was 5mu TIW for 16 weeks and for hepatitis C was 3mu TIW for 24 weeks. At the end of treatment, HbeAg was eliminated from 3 patients. From 10 patients chosen, from none of them the HBsAg was not eliminated at the end of 4 months treatment. In comparison with 10% elimination of HBsAg in treated groups that have been reported in other countries, our results demonstrated that interferon therapy is less effective in Asian patients in comparison with western patients.
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