Volume 64, Issue 11 (7 2006)                   Tehran Univ Med J 2006, 64(11): 81-86 | Back to browse issues page

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D Jamali Zavareii. M, Jarrahi. MR. Unilateral multifocal testicular biopsies in 320 patients with Germ Cell Aplasia. Tehran Univ Med J. 2006; 64 (11) :81-86
URL: http://tumj.tums.ac.ir/article-1-5588-en.html
Abstract:   (3913 Views)
Background: Germ cell aplasia (G.C.A) is one of the most important testicular causes of infertility and azospermia.In this condition the seminiferous tubules are only lined by a single layer of sertoli cell. In some cases, there is focal area with spermatogenic activity.
Methods: We studied infertile men with G.C.A referred to Jahade Daneshgahi of Iran during 1381-82, retrospectively. All the cases had more than one biopsy of one testis.
Results: In 11.6٪ of 320 cases, comparison of multiple biopsy sites of a testis revealed: when one site showed G.C.A, another site revealed areas with spermatogenic activity. Considering the cases who showed germ cells in both sites, 15.3٪ of cases multiple biopsy sites appeared to have focal spermatogenesis, better maturation of germ cells or higher scoring area for urologic operation.
Conclusion: According to new techniques in treatment of infertility with ICSI (intra cytoplasmic sperm injection) in which fertility is possible with one spermatozoa or even spermatid (after recovery), biopsy of multiple sites instead of only one site is highly recommended in azospermic patient.
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