Volume 68, Issue 8 (November 2010)                   Tehran Univ Med J 2010, 68(8): 481-486 | Back to browse issues page

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Afghani R, Aminian A, Mirsharifi S R, Jafarian A, Ghaderi H, Noaparast M et al . Serum homocysteine level and gall stone disease: a case control study. Tehran Univ Med J. 2010; 68 (8) :481-486
URL: http://tumj.tums.ac.ir/article-1-5655-en.html
1- Department of General Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. , af_med75@yahoo.com
2- Department of General Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:   (3910 Views)
Background: Gall stone is an important health problem in the world for which different risk factors have been characterized. Gall stone and cardiovascular disease have common risk factors. Homocysteine is accepted as one of the risk factors for cardiovascular disease. We aimed to study the effect of homocysteine level on gall stone formation.
Methods: 54 patients with gall stone-related diseases and 54 patients without stone (control group) were studied from January 2007 to December 2008. Control group consisted healthy subjects with ultrasound proven normal gallbladder. Serum homocysteine level was checked in both groups. Homocysteine level of equal or more than 15 mmol/l was considered as abnormally high.
Results: Cases included 43 women (79.6%) and had mean age of 50.76±15.23 years. Homocysteine level was significantly higher in patients with gallstone in comparison to control group (p=0.014). Risk of gall stone increased 3.4 times in persons who have homocysteine level equal or greater than 15mmol/l (p=0.019). The mean level of homocysteine was higher in men than women (p=0.03). The mean level of homocysteine did not differ significantly in patients with simple gallstone and patients with gallstone-related inflammation disorders (cholecystitis, cholangitis, and pancreatitis). Additionally, one unit increase in BMI level was associated with 1.12 times increase in the risk for gall stone formation (p=0.035).
Conclusion: The homocysteine level is increased in patients with gall stone-related diseases. Homocysteine may be considered as a risk factor of gall stone formation.
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