Volume 70, Issue 7 (6 2012)                   Tehran Univ Med J 2012, 70(7): 452-456 | Back to browse issues page

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M F, A T, M S, S N, Sh J N, Gh G. Superantigens in polyp tissue of patients with chronic rhino-sinusitis, a comparative study: a brief report. Tehran Univ Med J. 2012; 70 (7) :452-456
URL: http://tumj.tums.ac.ir/article-1-99-en.html
1- , cpidir@gmail.com
Abstract:   (4356 Views)

Background: Staphylococcus aureus secretes numerous superantigenes which trigger the inflammatory mechanisms of sinus mucosa and cause chronic rhino-sinusitis. This study was designed to evaluate the role of staphylococcus aureus superantigens in polyp tissues of patients with chronic rhino-sinusitis in comparison with a control group.
Methods: Polyp tissue samples of 28 patients and mucosal specimens of 19 healthy individuals were evaluated for staphylococcus aureus bacterium superantigens, exotoxins A, B, C and D and TSST-1 with RT-PCR and ELISA methods Rasoul Akram Hospital during 2 years.
Results: Polymerase chain reaction (PCR) results revealed that 88.2% of the patients and 45.5% of the controls had at least one type of superantigen (P=0.03). Evaluation of superantigens using ELISA method showed presence of at least one type of superantigen in the nasal samples of all patients and in 35.3% of the controls (P<0.001).
Conclusion: A relationship between staphylococcal superantigens and nasal polyps is concluded from this study which indicates the probable role of these superantigens in the pathogenesis of nasal polyposis.

Keywords: ELISA, RT-PCR, superantigens
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