Volume 64, Issue 2 (30 2006)                   Tehran Univ Med J 2006, 64(2): 180-188 | Back to browse issues page


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Izadyar M, Sedighipourand L, Jafarieh H, Fatahi F. Evaluation Of compliance To Iron Chelation Therapy With Defe-Roxamine In Patients With Major Thalassemia In Iran In 2004 . Tehran Univ Med J. 2006; 64 (2) :180-188
URL: http://tumj.tums.ac.ir/article-1-995-en.html

Abstract:   (3167 Views)

Background and Aim: With the introduction of long term subcutaneous administration of Deferoxamine there has been a decline in the morbidity and mortality of transfusion-dependent beta thalassemia patients. But parenteral iron chelation therapy is still a burden and a major reason for unsatisfactory compliance and places an additional psychological burden on the patients. There are some factors contributing to low compliance in these patients. To evaluate compliance to Deferoxamine and barriers of non adherence and assessment the prevalence of depression and it’s association with compliance.

Materials and Methods: 205 patients with major thalassemia in children medical center older than 6 years old were included. They were classified in 3 groups by compliance index (CI: No. of days of treatment per one month/No. of treatment days prescribed by physician). CI>75 % was considered good ,CI< 50-75%: moderate,CI<50%:weak and 3d group the patients without compliance. For assessment of depression: Beck Depression questionnaires were given to the patients older than 18 years old and Children Depression Inventories (CDI)“kovacs” were given to the rest

Results: Of 205 patients (110 females (54%) and 95 males (46%)), 13.3% were non compliant, 14% had poor compliance, 62.7% had good compliance. Females were more compliant than males (P=0.034). Compliance improved in older age groups meaningfully (P=0.037). There was negative association between compliance and serum ferritin level (P=0.02). 22% of children and 12% of Adults had severe depression according to the questionnaires. There was no association between compliance and depression. The most prevalent problem rgarding Desferal injection was local reactions in injection site (83%).

Conclusion: As oral chelation therapies are not used routinely, more investigations regarding the noncompliance must be considered and this method of chelation therapy must be encouraged. Compliance is a multifactorial problem, so the solution to which requires close interaction between the patient, the family and community.

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