Volume 59, Issue 1 (7 2001)                   Tehran Univ Med J 2001, 59(1): 21-25 | Back to browse issues page

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Keihani MD, Nakhjavani M. The role of GAD65 autoantibody in diabetes mellitus and their first-degree relatives and comparison with healthy persons. Tehran Univ Med J. 2001; 59 (1) :21-25
URL: http://tumj.tums.ac.ir/article-1-1347-en.html
Abstract:   (8701 Views)
The diabetes is an autoimmune disease, in which the role of autoantibodies is of a specific importance. The appearance of these autoantibodies can be the first symptom in the serum of type I diabetic patients, which may appear ten years before onset of the disease. The most important autoantibodies include Glutamic acid decarboxylase autoantibodies (GAD65-Ab). This can be used as a good tool for prediction in screening tests in type I diabetic patients. In the present study with prosedure RIA, we investigated the level of GAD65-Ab in patients with diabetes type I and their close relatives, and compared them with healthy persons. From the type I diabetic patients who have been suffering from the disease for periods of one week to twenty years, 63.3% of them had positive Anti-GAD65. This ratio was 8% in their close trelatives, and 0% in healthy persons. The difference in Anti-GAD65 between the healthy persons and close relative of patients was significant. This test may be employed in diabetes type I, as a screening test, and confirms the results of studies which have been conducted so far outside this country.
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