Volume 64, Issue 6 (3 2006)                   Tehran Univ Med J 2006, 64(6): 5-18 | Back to browse issues page

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Abstract:   (8650 Views)
MicroRNAs form a class of small non-coding RNA molecules. With only 21-23 nucleutide in length, they have an important role in gene expression. These molecules bind to their target mRNA molecules and repress the protein expression via mRNA degradation or blocking the translation machine of the cell. From the advent of molecular biology microRNA molecules were out of focus, however huge amount of studies in the past few years revealed a lot of facts about their nature. Nowadays around 1600 different microRNA are discovered in human, animals, plant and even viruses. In this review article the most recent data in the history, genes, expression and process of these molecules are introduced. Furthermore, the findings about diverse roles of these molecules in normal and abnormal conditions, cancer in particular, are shown. Finally, the differences to siRNA molecules and the prospect of microRNA have been explained.
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