Tehran University Medical Journal
مجله دانشکده پزشکی، دانشگاه علوم پزشکی تهران
Tehran Univ Med J
Medical Sciences
http://tumj.tums.ac.ir
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1683-1764
1735-7322
10.18869/acadpub.tumj
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jalali
1391
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gregorian
2012
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عوارض سیستمیک ناشی از استفاده همزمان داروهای توپیکال چشمی در یک پسر 17 ساله کاندیدای ویترکتومی عمیق: گزارش موردی
Systemic side-effects of topical ophthalmic drops in a 17-year old boy candidate for deep viterectomy: a case report
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<!--stripped--></p><strong><span style="font-size: 10pt">زمینه:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">داروهای توپیکال چشمی میتوانند
با درجات متفاوتی بهطور سیستمیک جذب شوند و قابلیت ایجاد عوارض سیستمیک جدی را
دارا هستند. بهویژه کودکان در برابر بروز عوارض سیستمیک داروهای توپیکال چشمی که
دوز آنها مطابق با وزن آنها تجویز نمیشود، آسیبپذیر هستند. </span>
<p style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">معرفیبیمار: </span></strong><span style="font-size: 10pt">در این گزارش عوارض سیستمیک ناشی از استفاده همزمان
داروهای توپیکال فنیل افرین، تتراکایین، تروپیکامید و آتروپین را در یک پسر 17
ساله کاندیدای ویترکتومی عمیق در بیمارستان فارابی در سال 1389 بررسی میکنیم. پس
از چند بار استفاده از ترکیب این قطرهها بیمار دچار علایم افزایش فشارخون و کاهش
هوشیاری میشود. </span><strong><em></em></strong></p>
<p style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">نتیجهگیری</span><span style="font-size: 10pt">:</span></strong><span style="font-size: 10pt"> </span><span style="font-size: 10pt">تعداد قطرهها و چندین بیمار استفاده پیاپی از قطرهها میتواند
سبب بروز عوارض ناشی از مصرف زیاد این قطرهها شود استفاده از غلظت پایین دارو،
استفاده از یک نوع دارو، قطرههای کوچک دارو و مسدود کردن سوراخ مجرای اشکی برای
به حداقل رساندن جذب دارو نتایجی هستند که از این مطالعه بهدست آمد و لازم است که
جهت پیشگیری از دوز توکسیک در بدن بیمار رعایت شوند.</span><strong><em></em></strong></p>
<p style="text-align: justify"><strong>Background</strong>: Drugs applied topically to the eye may be absorbed systemically to a substantial degree, with the potential to cause serious systemic side-effects. Children may be particularly vulnerable to systemic effects of topically applied agents as topical doses are often not weight-adjusted.<br><strong></strong></p>
<p style="text-align: justify"><strong>Case presentation</strong>: This article describes a case of serious systemic side-effect by the use of topical phenylephrine, tetracaine, tropicamide and atropine in a 17-year old boy candidate for deep viterectomy in Farabi Hospital in 1389. Following application of the aforesaid eye drops, the patient developed hypertension and subsequent loss of conciseness.<br><strong></strong></p>
<p style="text-align: justify"><strong>Conclusion</strong>: Several types of eye drops and their repeated use can lead to their systemic absorption and medical complications due to overdose. Strategies to minimize systemic absorption should be applied, including use of low concentrations of ophthalmic drugs, administration of one type of the drug, use of microdrops and punctal occlusion to minimize absorption via the nasolacrimal duct. While administering ophthalmic drops, one should take these precautions to minimize the systemic effects of the drugs to prevent subsequent complications.</p>
عوارض سیستمیک,داروهای توپیکال چشمی,فنیل افرین,تتراکایین,تروپیکامید,آتروپین,افزایش فشارخون,کاهش سطح هوشیاری
atropine,phenylephrine,systemic side-effects,tetracaine,topical ophthalmic medications,tropicamide
270
274
http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-129&slc_lang=fa&sid=1
Zahedi
H
حمید
زاهدی