Tehran University Medical Journal
مجله دانشکده پزشکی، دانشگاه علوم پزشکی تهران
Tehran Univ Med J
Medical Sciences
http://tumj.tums.ac.ir
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1683-1764
1735-7322
10.18869/acadpub.tumj
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jalali
1390
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بررسی ایمونوهیستوشیمی فعالیت اولین ایزوفرم آنزیم آلدهید دهیدروژناز در مبتلایان به سرطان پستان و ارتباط آن با خصوصیات پاتولوژیک تومور
The immunohistochemical assessment of ALDH1 activity in breast cancer and it’s correlation with pathologic features
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<p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">زمینه و هدف:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">اولین
ایزوفرم آنزیم آلدهید دهیدروژناز<strong> </strong></span><span style="font-size: 7pt">(ALDH1)</span><span style="font-size: 10pt"> مارکر سلولهای بنیادی و سرطانی پستان بوده و بروز آن احتمالا با پروگنوز بدتر
تومور همراه میباشد. انجام مطالعاتی در جهت شناسایی سلولهای </span><span style="font-size: 7pt">ALDH1+</span><span style="font-size: 10pt"> میتواند به درمان بیماران سرطان پستان کمک
نماید. هدف از این مطالعه تعیین میزان فعالیت آنزیم </span><span style="font-size: 7pt">ALDH1</span><span style="font-size: 10pt"> در سرطان پستان و ارتباط آن با خصوصیات پاتولوژیک تومور میباشد.</span><span style="font-size: 9pt"> </span><strong><span style="font-size: 10pt"><br></span></strong></p><p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">روش بررسی:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">میزان فعالیت </span><span style="font-size: 7pt">ALDH1</span><span style="font-size: 10pt"> در نمونههای بافتی پارافینی 121 بیمار
مبتلا به کانسر پستان مراجعهکننده به بخش پاتولوژی بیمارستان میلاد تهران توسط
آزمایش ایمونوهیستوشیمی سنجیده شد، سپس ارتباط آن با خصوصیات پاتولوژیک تومور
(سایز، </span><span style="font-size: 8pt">Grade</span><span style="font-size: 10pt">، درگیری لنف نود یا عروق) مورد بررسی قرار
گرفت.<strong> </strong></span><strong><span style="font-size: 10pt"><br></span></strong></p><p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">یافتهها:</span></strong><span style="font-size: 10pt"> </span><span style="font-size: 10pt">1/85% از
نمونههای سرطان پستان مورد بررسی با درجات متفاوتی (ضعیف، متوسط، قوی) </span><span style="font-size: 7pt">ALDH1</span><span style="font-size: 10pt"> را در سیتوپلاسم بیان میکردند. 18 مورد
(9/14%) نیز از نظر </span><span style="font-size: 7pt">ALDH1</span><span style="font-size: 10pt"> منفی بودند. </span><span style="font-size: 7pt">ALDH1</span><span style="font-size: 10pt"> در اکثر موارد (1/97%) در استرومای نمونههای تهیهشده مثبت بود که شدت آن از رنگآمیزی
ضعیف (9/2%) تا قوی (5/73%) متغیر بود. </span><span style="font-size: 7pt">ALDH1 H</span><span style="font-size: 8pt">-score</span><span style="font-size: 10pt"> <span lang="FA">(درصد سلولهای </span></span><span style="font-size: 7pt">ALDH1</span><span style="font-size: 10pt"> مثبت ×</span><span style="font-size: 8pt">Intensity </span><span style="font-size: 10pt">) در سلولهای تومورال از صفر تا 240 متغیر
بوده و میانگین آن 80 بود. میزان </span><span style="font-size: 7pt">ALDH1 H</span><span style="font-size: 8pt">-score</span><span style="font-size: 10pt"> در 62 مورد (2/51%) کمتر یا مساوی 80 و در
59 مورد (8/48%) بیشتر از 80 بود. اما</span><span style="font-size: 10pt"> </span><span style="font-size: 10pt">بین </span><span style="font-size: 7pt">ALDH1 H</span><span style="font-size: 8pt">-score</span><span style="font-size: 10pt"> با سن بیماران
(358/0</span><span style="font-size: 7pt">P=</span><span style="font-size: 10pt">)،
سایز تومور (375/0</span><span style="font-size: 7pt">P</span><span style="font-size: 7pt">=</span><span style="font-size: 10pt">)، </span><span style="font-size: 8pt">Grade</span><span style="font-size: 10pt"> تومور (207/0</span><span style="font-size: 7pt">P</span><span style="font-size: 7pt">=</span><span style="font-size: 10pt">)</span><span style="font-size: 10pt">، و میزان تهاجم به لنف نود (125/0</span><span style="font-size: 7pt">P=</span><span style="font-size: 10pt">) یا عروقی خونی (190/0</span><span style="font-size: 7pt">P</span><span style="font-size: 7pt">=</span><span style="font-size: 10pt">)</span><span style="font-size: 10pt"> ارتباط معنیداری وجود نداشت.</span><strong><span style="font-size: 10pt"> <br></span></strong></p><p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">نتیجهگیری:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">فعالیت </span><span style="font-size: 7pt">ALDH1</span><span style="font-size: 10pt"> در 1/85% از
موارد تومور پستان مثبت است و میزان فعالیت آن با ویژگیهای پاتولوژیک تومور رابطه
معنیداری ندارد.</span></p>
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<!--stripped--> <strong>Background:</strong><strong> </strong>Aldehyde
dehydrogenase 1 (ALDH1) is a marker of normal and malignant human mammary
stem cells that has been reported to be associated with poor prognosis. Studies
on the detection of ALDH1+ cells can help the treatment of patients with
breast cancer. The aim of this study was to determine the activity of ALDH1 in breast
cancer and its relationship with the pathological features of the tumors.<br><strong>Methods:</strong> <strong> </strong>ALDH1 activity was studied by
immunohistochemistry in 121 paraffin-embedded histological
samples of breast cancer patients from Department of Pathology of Milad
Hospital, Tehran, Iran during 2006-2007. The
relationship of ALDH1 with the pathological features of the tumors (size,
grade, lymph node metastasis and vascular invasion) was also investigated.<br><strong>Results:</strong> <strong> </strong>Eighty-five percent of breast cancer
samples expressed ALDH1 in their cytoplasm with a wide range
of intensity (weak, moderate and strong), while 18 samples (14.9%) were completely negative. The
majority of cases (97.1%) showed ALDH1 positivity in the stroma of tumors which varied from
weak (2.9%) to strong (73.5%). ALDH1 H-score (ALDH1% × intensity) of tumor cells varied from 0 to 240 (mean= 80). ALDH1 H-score was ≤80 in 62 (51.2%) and >80 in 59 (48.8%) samples. There
was no statistically significant relationship between ALDH1 H-score and age (P=0.358), tumor size (P=0.375), tumor grade (P=0.207), lymph node metastasis (P=0.125) or vascular
invasion (P=0.190).<br><strong>Conclusion: </strong> ALDH1 activity was
demonstrated in 85.1% of
breast cancer samples although its level of expression was not correlated with
the pathologic features of breast tumors.</p>
ALDH1،کانسر پستان،سلولهای بنیادی سرطان
ALDH1,breast cancer,cancer stem cells
529
536
http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-191&slc_lang=fa&sid=1
Ramezani
B
بابک
رمضانی