Tehran University Medical Journal
مجله دانشکده پزشکی، دانشگاه علوم پزشکی تهران
Tehran Univ Med J
Medical Sciences
http://tumj.tums.ac.ir
1
admin
1683-1764
1735-7322
10.18869/acadpub.tumj
000
000
000
fa
jalali
1390
7
1
gregorian
2011
10
1
69
7
online
1
fulltext
fa
تومورهای مزانشیمال مری و معده: بررسی 24 بیمار
Esophagogastric mesenchymal tumors: analysis of 24 patients
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<p dir="rtl" style="margin-top: 6pt text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">زمینه و
هدف:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">تومورهای مزانشیمال گوارشی جزو تومورهای با منشاء عضلات صاف
طبقهبندی میشدند. </span><span style="font-size: 8pt">Gastrointestinal Stromal Tumors</span><span style="font-size: 8pt"> </span><span style="font-size: 7pt">(GIST)</span><span style="font-size: 10pt"> شایعترین نوع تومورهای مزانشیمال گوارشی هستند که در سرتاسر لوله گوارش از مری تا
آنوس دیده میشود و اکثر موارد آن در معده اتفاق میافتد. بیشتر بیماران مبتلا به </span><span style="font-size: 7pt">GIST</span><span style="font-size: 10pt"> بدون علامت هستند و درمان آن در اکثر موارد
جراحی است. هدف ما در این مطالعه بررسی </span><span style="font-size: 7pt">GIST</span><span style="font-size: 10pt"> تومورهای مری و معده بوده است. <br></span></p><p dir="rtl" style="margin-top: 6pt text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><span style="font-size: 10pt"></span><strong><span style="font-size: 10pt">روش بررسی:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">در یک مطالعه گذشتهنگر بیمارانی که بین سالهای 1370 تا
1388 با تشخیص تومور مزانشیمال مری و معده در بیمارستان قائم </span><span style="font-size: 9pt">(عج)</span><span style="font-size: 10pt"> و
امید مشهد بستری و تحت درمان قرار گرفته بودند مورد <span> </span>بررسی قرار گرفتند.<strong> </strong></span><strong><em><span style="font-size: 10pt"><br></span></em></strong></p><p dir="rtl" style="margin-top: 6pt text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">یافتهها:</span></strong><span style="font-size: 10pt"> </span><span style="font-size: 10pt">24 بیمار وارد مطالعه شدند (16 نفر
مرد و هشت نفر زن) میانگین سنی 50 سال<span></span><span> </span>بود، شایعترین محل تومور در فوندوس معده بود.
تمام بیماران در حین تشخیص علامتدار بوده و شایعترین علامت در بیماران احساس پری
بود که در 50% از بیماران وجود داشت. شایعترین عمل جراحی انجامشده در<span> </span><span> </span>این
بیماران گاسترکتومی سابتوتال بود. مرگ و میر بیمارستانی ثبت نشده بود. عوارض در پنج
بیمار (5/20%)<span> </span><span> </span>بعد از عمل دیده شد که شایعترین آن ایلئوس بعد
از عمل بوده است، درمان کمکی بعد از عمل که در هشت<span> </span><span> </span>بیمار
(1/33%) استفاده گردید، در پیگیری سه ساله تنها سه بیمار فوت نمودند (45/12%). </span><strong><em><span style="font-size: 10pt"><span><br></span></span></em></strong></p><p dir="rtl" style="margin-top: 6pt text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><em><span style="font-size: 10pt"><span></span></span></em><span style="font-size: 10pt">نتیجهگیری:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">با
توجه به نتایج مناسب جراحی در این بیماران با عوارض مرگ و میر اندک، جراحی بهعنوان
درمان انتخابی در بیمارانی <span> </span>که توانایی
جراحی را دارند توصیه میگردد.</span></p>
<p style="text-align: justify"><strong>Background:</strong> Gastrointestinal mesenchymal tumors are classified as tumors that originate from smooth muscles. Gastrointestinal stromal tumors (GIST) are the most common types of the proposed tumors and can be seen in the GI tract from the esophagus to the anus, but they are mostly seen in the stomach. Mostly from the stomach and asymptomatic, the majority of patients would benefit from surgery as the best method of treatment.<br><strong></strong></p>
<p style="text-align: justify"><strong>Methods:</strong> In this retrospective study we evaluated the data of patients with the diagnosis of esophageal or gastric mesenchymal tumors admitted in Ghaem and Omid Hospitals affiliated to Mashhad University of Medical Sciences in Iran, from 1992 to 2010. We analyzed factors such as age, sex, presenting symptoms and signs, diagnostic methods, types of pathology, types of treatment, morbidity, mortality and 3-year survival rates.<br><strong></strong></p>
<p style="text-align: justify"><strong>Results:</strong> Twenty four patients (16 male, 8 female) with a mean age of 50 were included in the study. The common site of tumor was gastric fundus. The most common symptom at the time of diagnosis was epigastric fullness which was observed in almost 50% of the patients. The most common type of surgery in the patients was subtotal gastrectomy and no hospital mortality was recorded. Paralytic ileus was the commonest complication seen in five patients (20.5%). Adjuvant therapy had been performed in eight patients (33.1%). Following the patients three years postoperatively, there were only three deaths (12.45%).<br><strong></strong></p>
<p style="text-align: justify"><strong>Conclusion:</strong> Regarding to the low mortality and morbidity of the surgeries, surgical treatment, if tolerated, is recommended for all Esophagogastric mesenchymal tumors patients.</p>
تومور مزانشیمال مری و معده،تشخیص،درمان،عوارض،مرگ و میر
Complication,diagnosis,gastroesophageal,mesenchymal tumor,mortality,treatment
438
444
http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-215&slc_lang=fa&sid=1
Bagheri
R
رضا
باقری