Volume 83, Issue 7 (October 2025)
Tehran Univ Med J 2025, 83(7): 490-497 |
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Teymurinejad A, Seidkhani H, Mohebinejad Z, Eidypou A, Azadi H. Comparison of the analgesic efficacy of pethidine and ketorolac in renal colic patients.. Tehran Univ Med J 2025; 83 (7) :490-497
URL: http://tumj.tums.ac.ir/article-1-13740-en.html
URL: http://tumj.tums.ac.ir/article-1-13740-en.html
1- Department of Urology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
2- Department of Biostatistics, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran. ,hseidkhani@gmail.com
3- Ilam Health Center, Health Department, Ilam University of Medical Sciences, Ilam, Iran.
4- Department of Anesthesiology, Faculty of Paramedical, Ilam University of Medical Sciences, Ilam, Iran.
2- Department of Biostatistics, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran. ,
3- Ilam Health Center, Health Department, Ilam University of Medical Sciences, Ilam, Iran.
4- Department of Anesthesiology, Faculty of Paramedical, Ilam University of Medical Sciences, Ilam, Iran.
Abstract: (30 Views)
Background: Kidney stones are the third most common urinary tract disorder after prostate disease and infection. Painful attacks are the most common clinical manifestation, which is known as renal colic. The aim of the present study is to determine the effect of pethidine, pethidine and ketorolac, and ketorolac in patients with primary renal colic.
Methods: Renal colic patients at Imam Khomeini Hospital in Ilam from April 2023 and March 2023. were divided into three groups of 36 people. The first group received pethidine 25 mg, the second group received ketorolac 30 mg, and the third group received a combination of 2 drugs. A questionnaire included demographic information of the patients, heart rate, systolic and diastolic blood pressure, respiratory rate, oxygen saturation, side effects, pain intensity, length of hospitalization, and type of treatment received.
Results: After receiving the drug, the average heart rate increased in all three groups. But in group A, this increase was less than two groups, B and C, and this difference was not statistically significant (P=0.34). The average systolic blood pressure before receiving the drug was significantly higher in the three studied groups (P=0.006), which decreased after receiving the drug, but this decrease in systolic blood pressure in the three groups was not statistically significant (P=0.98). The average pain intensity before receiving the drug was 8.56 ± 1.2 in group A, 9.17 ± 0.878 in group B, and 8.86 ± 0.961 in group C. There was no significant difference between the three groups in terms of initial pain intensity (P=0.45). While the average pain intensity after receiving the medicine was significantly reduced and there was a significant difference (P<0.000).
Conclusion: Overall, the obtained results showed that ketorolac and pethidine have a faster effect and power compared to pethidine and ketorolac alone in controlling the pain of patients with renal colic, and the need for life-saving treatment is also less in this drug, and according to numerous studies, its side effects are also less.
Methods: Renal colic patients at Imam Khomeini Hospital in Ilam from April 2023 and March 2023. were divided into three groups of 36 people. The first group received pethidine 25 mg, the second group received ketorolac 30 mg, and the third group received a combination of 2 drugs. A questionnaire included demographic information of the patients, heart rate, systolic and diastolic blood pressure, respiratory rate, oxygen saturation, side effects, pain intensity, length of hospitalization, and type of treatment received.
Results: After receiving the drug, the average heart rate increased in all three groups. But in group A, this increase was less than two groups, B and C, and this difference was not statistically significant (P=0.34). The average systolic blood pressure before receiving the drug was significantly higher in the three studied groups (P=0.006), which decreased after receiving the drug, but this decrease in systolic blood pressure in the three groups was not statistically significant (P=0.98). The average pain intensity before receiving the drug was 8.56 ± 1.2 in group A, 9.17 ± 0.878 in group B, and 8.86 ± 0.961 in group C. There was no significant difference between the three groups in terms of initial pain intensity (P=0.45). While the average pain intensity after receiving the medicine was significantly reduced and there was a significant difference (P<0.000).
Conclusion: Overall, the obtained results showed that ketorolac and pethidine have a faster effect and power compared to pethidine and ketorolac alone in controlling the pain of patients with renal colic, and the need for life-saving treatment is also less in this drug, and according to numerous studies, its side effects are also less.
Type of Study: Original Article |
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