Volume 74, Issue 10 (January 2017)                   Tehran Univ Med J 2017, 74(10): 723-734 | Back to browse issues page

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Tartibian B, Sheikhlou Z, Malandish A, Rahmati-Yamchi M, Afsar Garebag R. Effect of moderate-intensity aerobic training on alkaline phosphatase gene expression and serum markers of bone turnover in sedentary postmenopausal women . Tehran Univ Med J. 2017; 74 (10) :723-734
URL: http://tumj.tums.ac.ir/article-1-7838-en.html
1- Department of Exercise Physiology, Department of Sport Injury and Corrective, School of Physical Education and Sport Sciences, Allameh Tabataba'i University, Tehran, Iran.
2- Department of Exercise Physiology, Urmia University, Urmia, Iran. , z.sheikhlou@gmail.com
3- Department of Exercise Physiology, Urmia University, Urmia, Iran.
4- Department of Clinical Biochemistry, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5- Department of Interventional Cardiology, Urmia University of Medical Sciences, Urmia, Iran.
Abstract:   (2442 Views)

Background: Studies show that aerobic exercise prevents osteoporosis in menopause by stimulating osteoblastic cells. Therefore, the purpose of this study was to investigate the effect of 12 weeks of moderate-intensity aerobic exercise on alkaline phosphatase gene expression, serum levels of alkaline phosphatase, parathyroid hormone, and calcium in sedentary women.

Methods: This investigation is a semi-experimental study that was performed in September 2015 at Urmia University, Iran. The statistical population was all healthy and sedentary postmenopausal women 50 to 65 years old in Urmia city. Twenty sedentary postmenopausal women with an average age 60.12±2.12 yr, weight 72.35±10.50 kg, and body mass index 29.46±3.24 kg/m2 voluntarily and bona fide participated in this study, and then subjects were randomly divided to the Exercise/E (10 women) and Control/C (10 women) groups by random sampling method. E group performed of 12 weeks walking and jogging moderate-intensity aerobic exercise at 65-70% maximal heart rate of training, three sessions per week and per session 50-60 (min), but the C group participated in no intervention. Twenty-four hours before and after the 12-week training program were taken blood samples in order to measure of alkaline phosphatase gene expression and serum markers of bone in the E and C Groups. Evaluation of gene expression and serum markers of bone were measured by real-time reverse transcription PCR (RT-PCR) and Auto-analyzer (Biotechnica, Italy)/ ELISA reader (Awareness Inc., USA) machines, respectively. Data analysis included descriptive and inferential (ANCOVA test) statistics using SPSS version 23 (Chicago, IL, USA) and a significance level of P≥0.05 was considered.

Results: The results showed that alkaline phosphatase gene expression and parathyroid hormone after 12 weeks of moderate-intensity aerobic exercise in between-groups were significantly increased (P=0.027 and P=0.006, respectively), while serum levels of calcium and alkaline phosphatase were not significantly different (P=0.941 and P=0.990, respectively).

Conclusion: The results suggest that 12 weeks of aerobic exercise of walking and jogging at 65-70% maximal heart rate of training increases alkaline phosphatase gene expression and parathyroid hormone in sedentary postmenopausal women.

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Type of Study: Original Article |

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