Volume 76, Issue 3 (June 2018)
Tehran Univ Med J 2018, 76(3): 211-215 |
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Mousazadeh S, Rahimi A, Gosili R, Ghaheri A, Khaksar F. The function of factors and exacerbation of polycystic ovary syndrome: brief report. Tehran Univ Med J 2018; 76 (3) :211-215
URL: http://tumj.tums.ac.ir/article-1-8836-en.html
URL: http://tumj.tums.ac.ir/article-1-8836-en.html
1- Department of Genetics, Caucasus Infertility Treatment Center, ACECR, Ardabil Branch, Ardabil, Iran.
2- Department of Cellular and Molecular Biology, School of Basic Sciences and Biotechnology, University of Science and Culture, Tehran, Iran.
3- Department of Obstetrics, Caucasus Infertility Treatment Center, ACECR, Ardabil Branch, Ardabil, Iran. , royagosili@yahoo.com
4- Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute, Tehran, Iran.
5- Department of Biology, School of Basic Sciences, Mohaghegh Ardabili University, Ardabil, Iran.
2- Department of Cellular and Molecular Biology, School of Basic Sciences and Biotechnology, University of Science and Culture, Tehran, Iran.
3- Department of Obstetrics, Caucasus Infertility Treatment Center, ACECR, Ardabil Branch, Ardabil, Iran. , royagosili@yahoo.com
4- Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute, Tehran, Iran.
5- Department of Biology, School of Basic Sciences, Mohaghegh Ardabili University, Ardabil, Iran.
Abstract: (3619 Views)
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and one of the main reasons of infertility in women. PCOS causes many symptoms in women, one of the most important of them is ovulation failure. It affects the women at the age of fertility. Many factors are detected to exacerbate PCOS including insulin, anti-Mullerian hormone, obesity and androgen. The aim of this study was to evaluate endocrine and metabolic factors and its relation with obesity in patients with polycystic ovary syndrome in exacerbation of disease.
Methods: This cross-sectional study was carried out at the Caucasus Infertility Treatment Center of Ardabil from July 2015 to March 2016 and on 321 patients with polycystic ovary syndrome. Blood samples were investigated to measure serum levels of fasting insulin, dehydroepiandrosterone sulfate (DHEAS), 17OHP, fasting blood sugar, sex hormone binding globulin (SHBG), anti-Mullerian hormone, vitamin D, total testosterone, free testosterone, prolactin, FSH, LH and TSH. Also, body mass index (BMI), duration of infertility and age were measured. BMI was evaluated to measure the obesity of patients.
Results: We were able to demonstrate significantly high level of total testosterone and fasting insulin in PCOS women by having weight gain (P< 0.05). Response to drug was significantly increased with reduced weight of these patients (P= 0.02). The level of fasting blood sugar (P= 0.01) and anti-Mullerian hormone (P< 0.05) were increased significantly with access in PCOS. On the other hand, our data showed that duration of infertility was increased by growing the age of patients (P< 0.05).
Conclusion: Insulin resistance, obesity, hyperandrogenism and metabolic syndrome are very important factors in pathogenesis of PCOS. These factors could affect the fertility of women by effecting the reproductive processes. Therefore, it is better in the patients who are older, treatment strategies further underline on reduce these factors (insulin resistance, obesity and hyperandrogenism) to prevent disease progression and increase duration of infertility.
Methods: This cross-sectional study was carried out at the Caucasus Infertility Treatment Center of Ardabil from July 2015 to March 2016 and on 321 patients with polycystic ovary syndrome. Blood samples were investigated to measure serum levels of fasting insulin, dehydroepiandrosterone sulfate (DHEAS), 17OHP, fasting blood sugar, sex hormone binding globulin (SHBG), anti-Mullerian hormone, vitamin D, total testosterone, free testosterone, prolactin, FSH, LH and TSH. Also, body mass index (BMI), duration of infertility and age were measured. BMI was evaluated to measure the obesity of patients.
Results: We were able to demonstrate significantly high level of total testosterone and fasting insulin in PCOS women by having weight gain (P< 0.05). Response to drug was significantly increased with reduced weight of these patients (P= 0.02). The level of fasting blood sugar (P= 0.01) and anti-Mullerian hormone (P< 0.05) were increased significantly with access in PCOS. On the other hand, our data showed that duration of infertility was increased by growing the age of patients (P< 0.05).
Conclusion: Insulin resistance, obesity, hyperandrogenism and metabolic syndrome are very important factors in pathogenesis of PCOS. These factors could affect the fertility of women by effecting the reproductive processes. Therefore, it is better in the patients who are older, treatment strategies further underline on reduce these factors (insulin resistance, obesity and hyperandrogenism) to prevent disease progression and increase duration of infertility.
Type of Study: Brief Report |
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