The effect of high-intensity interval training on cardiac mitochondria PGC1α and some oxidative stress indices in mice with liver damage

Mokhtari, Maryam; Attarzadeh Hosseini, Seyyed Reza; Bijeh, Nahid; Mosaferi Ziaaldini , Mohammad

Volume 81, Issue 12 (March 2024) Tehran Univ Med J 2024, 81(12): 944-956 | Back to browse issues page

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Mokhtari M, Attarzadeh Hosseini S R, Bijeh N, Mosaferi Ziaaldini M. The effect of high-intensity interval training on cardiac mitochondria PGC1α and some oxidative stress indices in mice with liver damage. Tehran Univ Med J 2024; 81 (12) :944-956
URL: http://tumj.tums.ac.ir/article-1-12948-en.html

The effect of high-intensity interval training on cardiac mitochondria PGC1α and some oxidative stress indices in mice with liver damage

Maryam Mokhtari¹

, Seyyed Reza Attarzadeh Hosseini ^*

², Nahid Bijeh¹

, Mohammad Mosaferi Ziaaldini¹

1- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Mashhad, Iran.
2- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Mashhad, Iran. , attarzadeh@um.ac.ir

Abstract: (135 Views)

Background: Fatty liver disease is the most common cause of chronic liver diseases in the world, which can cause cardiovascular diseases, so this research aims to scrutiny a period of intense intermittent sports activity and growth hormone perfuse on cardiac mitochondrial PGC1α and some indicators of oxidative stress in mice with liver damage.

Methods: The present research was conducted from September 2022 to March 2023 in the specialized physical training laboratory of Ferdowsi University of Mashhad. The statistical population was twenty one adult male Syrian mice with an average weight of twenty three grams. The sports activity protocol was adopted for fifty-six days using the special video recorder for rodents. The intense interval training program was carried out in the form of ten one-minute repetitions and two-minute active rest, so that the total daily training time for each person was thirty minutes.The vaccination protocol includes the daily vaccination of somatropin injected intraperitoneally.
Results: The PGC1α levels were significantly higher in both the HIIT (P=0.02) and H- GH (P=0.03) groups collationed to the witness team. Moreover, the levels of SOD were considerably increased, in both the HIIT (P=0.05) and H-GH (P=0.005) team s compared to the witness team. Moreover, the levels of MDA were considerably decreased, in both the HIIT (P=0.007) and H-GH (P=0.04) teams compared to the witness team. The decrease in insulin resistance was significant only in the HIIT (P=0.05) team compared to the witness team and slightly increased in the H-GH (P=0.36) team but was not considered. The difference between HIIT and H-GH team (P=0.03) was also significant.The proportion of ALT/AST in both HIIT (P=0.02) and H-GH (P=0.03) teams had a significant decrease compared to the witness team. LDL/HDL proportion evidenced considered decrement at just in the HIIT team (P=0.01).
Conclusion: Intense intermittent sports activity was able to produce a more optimal response compared to GH peptide in improving NAFLD-related indices. Injection of this hormone single may have adverse outcomes on some indexes of this abnormality.

Keywords: enzymes, growth hormone, high-intensity interval training, lipid droplet associated proteins, oxidative stress, PPARGC1A protein, superoxide dismutase-1.

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Type of Study: Original Article |