Background: Macromastia can have a significant impact on patients’ quality of life by causing physical discomfort and psychological distress. Reduction mammoplasty can provide both aesthetic and therapeutic benefits. In cases of gigantomastia, where extreme breast hypertrophy prevents the use of traditional pedicled techniques, breast amputation with a free nipple graft is always a considered surgical option. There are different presented methods and designs for this procedure. This surgery is highly beneficial for patients, and most of them report significant improvements in their quality of life and overall satisfaction with the final results.
Case Presentation: In this study, we employed reduction mammoplasty and a free nipple graft with a vertical design and superior pedicle preservation in patients with gigantomastia who were referred to Tehran Imam Khomeini Hospital Clinic during a period of five years (February 2020–February 2025). The patients were out of the range of fertility and were in the range of obesity (most of them had a BMI of over 35(kg/m2)). Then, patient satisfaction and quality of life improvement were evaluated with a standard questionnaire. Finally, complications during and after surgery were recorded. The surgery was performed on 17 patients. The distance from the sternal notch to the nipple was more than 40 cm, and the distance from the nipple to the inframammary fold (IMF) was more than 20 cm in all patients (confirming gigantomastia). Therefore, they were not candidates for pedicled mammoplasty. All the patients were satisfied with the results. Their quality of life, posture, back pain, neck pain, and other symptoms improved significantly. We recorded no cardiovascular complications during or after surgery.
Conclusion: Breast amputation with a free nipple graft is an efficient method for treating gigantomastia and is very safe for patients with diabetes mellitus, cardiovascular diseases, high BMI, and those at infertile ages. A vertical design with superior pedicle preservation can provide both aesthetic and therapeutic benefits, leading to high patient satisfaction and improved quality of life.