Volume 83, Issue 3 (June 2025)
Tehran Univ Med J 2025, 83(3): 179-191 |
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Kafrashi S, Norouzi H, Safari M. Comparison of weight loss and short-term outcomes of endoscopic botulinum neurotoxin intragastric injection with sleeve gastrectomy surgery. Tehran Univ Med J 2025; 83 (3) :179-191
URL: http://tumj.tums.ac.ir/article-1-13547-en.html
URL: http://tumj.tums.ac.ir/article-1-13547-en.html
1- Department of Internal Medicine, Clinical Research Development Unit, Amiralmomenin Hospital, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
2- Department of Internal Medicine, Clinical Research Development Unit, Amiralmomenin Hospital, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran. ,hrn65@yahoo.com
3- Department of Biostatistics, Clinical Research Development Unit, Amiralmomenin Hospital, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
2- Department of Internal Medicine, Clinical Research Development Unit, Amiralmomenin Hospital, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran. ,
3- Department of Biostatistics, Clinical Research Development Unit, Amiralmomenin Hospital, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Abstract: (543 Views)
Background: In this study, Botox method is compared with sleeve gastrectomy as one of the endoscopic methods in the treatment of obesity for patients who are not effective in lifestyle and drug modification methods and do not have the interest or necessary conditions for bariatric surgery.
Methods: This Cross-sectional study was conducted in eligible patients who were outpatients at the gastroenterology clinics of Amir al-Momenin Hospital, Arak, in June 2014 for one year in the gastroenterology clinic after obtaining informed consent, demographic information, and anthropometric measurements. After 12 weeks, patients in both groups were visited again. In patients in group A (Botox group), endoscopy was performed by an experienced gastroenterologist under sedation after a 10-hour fast, and in patients in group B (sleeve gastrectomy) under general anesthesia, a partial and longitudinal gastrectomy was performed. The BAROS questionnaire was used to assess the quality of life of patients.
Results: The mean age of the subjects in the endoscopic botulinum neurotoxin group was 30.88±11.89 years and the sleeve gastrectomy group was 29.88±11.06 years. In this study, 12 subjects (24.0%) were male and 38 subjects (76%) were female. There was a significant difference in the mean body mass index and weight at four measurements in the two study groups (endoscopic botulinum neurotoxin and sleeve gastrectomy). There was no statistically significant difference in the mean blood pressure, laboratory results, and mean quality of life in the study groups.
Conclusion: Endoscopic botulinum injection in the stomach is an effective and safe method for short-term weight loss, but its long-term effect on weight and the occurrence of complications or metabolic effects requires long-term follow-up.
Methods: This Cross-sectional study was conducted in eligible patients who were outpatients at the gastroenterology clinics of Amir al-Momenin Hospital, Arak, in June 2014 for one year in the gastroenterology clinic after obtaining informed consent, demographic information, and anthropometric measurements. After 12 weeks, patients in both groups were visited again. In patients in group A (Botox group), endoscopy was performed by an experienced gastroenterologist under sedation after a 10-hour fast, and in patients in group B (sleeve gastrectomy) under general anesthesia, a partial and longitudinal gastrectomy was performed. The BAROS questionnaire was used to assess the quality of life of patients.
Results: The mean age of the subjects in the endoscopic botulinum neurotoxin group was 30.88±11.89 years and the sleeve gastrectomy group was 29.88±11.06 years. In this study, 12 subjects (24.0%) were male and 38 subjects (76%) were female. There was a significant difference in the mean body mass index and weight at four measurements in the two study groups (endoscopic botulinum neurotoxin and sleeve gastrectomy). There was no statistically significant difference in the mean blood pressure, laboratory results, and mean quality of life in the study groups.
Conclusion: Endoscopic botulinum injection in the stomach is an effective and safe method for short-term weight loss, but its long-term effect on weight and the occurrence of complications or metabolic effects requires long-term follow-up.
Type of Study: Original Article |
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