Volume 83, Issue 3 (June 2025)
Tehran Univ Med J 2025, 83(3): 218-225 |
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Bahadur M, Momeni Z. Evaluation and comparison of dose homogeneity index, sacrum bone dose and maximum rectal dose in endometrial and cervical cancer patients with two energies of 6 and 15 MV. Tehran Univ Med J 2025; 83 (3) :218-225
URL: http://tumj.tums.ac.ir/article-1-13551-en.html
URL: http://tumj.tums.ac.ir/article-1-13551-en.html
1- Department of Radiooncology, Afzalipour Hospital, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Abstract: (608 Views)
Background: Radiotherapy is one modalities for common cancers like cervical and endometrial. Although radiation therapy has side effects such as digestive problems and radiation-induced changes in the sacrum. At the current article, the factors that evaluate the side effects of radiation therapy for two energies of 6 and 15 megavoltage were compared.
Methods: For this study, the data of 50 female patients with an average age of 58.5 years with cervical and endometrial cancers were used. For each patient, the BOX treatment plan was carried out with Eclipse software for two energies, 6 and 15 MV, with total prescribed dose of 50 Gy. Along with factors such as dose homogeneity, sacrum bone dose, and maximum rectal dose were compared.
Results: The comparison reveals that the maximum rectal dose for 6 MV energy was significantly (Pvalue=0.001) more than those planed with 15 MV.
For the volume of the sacrum that receives a dose of 40 Gy (V_40), it was seen that for 6MV (99.86±0.42) energy, were significantly more than the treatment plan with 15 MV energy (99.83±0.48) (Pvalue=0.026). According to the homogeneity index for this study, a statistically significant difference was seen for the value obtained from HI2 and HI3 for 6 MV compared to 15 MV Pvalue<0.001, PValue=0.008 respectively which the treatment plans performed with 15 MV energy were more homogeneous than MV 6 energy.
Conclusion: In this article, it was observed that the use of low energies for the treatment of pelvic cancers, enhances the percentage of the maximum dose reached to healthy organs, which causes patients to suffer complications Therefore, it is recommended to use high energy, such as 15 MV, to reduce the side effects of radiotherapy, and also it has been suggested that patients should be followed up for 3 to 5 years in order to obtain more reliable information about the sacrum dose.
Methods: For this study, the data of 50 female patients with an average age of 58.5 years with cervical and endometrial cancers were used. For each patient, the BOX treatment plan was carried out with Eclipse software for two energies, 6 and 15 MV, with total prescribed dose of 50 Gy. Along with factors such as dose homogeneity, sacrum bone dose, and maximum rectal dose were compared.
Results: The comparison reveals that the maximum rectal dose for 6 MV energy was significantly (Pvalue=0.001) more than those planed with 15 MV.
For the volume of the sacrum that receives a dose of 40 Gy (V_40), it was seen that for 6MV (99.86±0.42) energy, were significantly more than the treatment plan with 15 MV energy (99.83±0.48) (Pvalue=0.026). According to the homogeneity index for this study, a statistically significant difference was seen for the value obtained from HI2 and HI3 for 6 MV compared to 15 MV Pvalue<0.001, PValue=0.008 respectively which the treatment plans performed with 15 MV energy were more homogeneous than MV 6 energy.
Conclusion: In this article, it was observed that the use of low energies for the treatment of pelvic cancers, enhances the percentage of the maximum dose reached to healthy organs, which causes patients to suffer complications Therefore, it is recommended to use high energy, such as 15 MV, to reduce the side effects of radiotherapy, and also it has been suggested that patients should be followed up for 3 to 5 years in order to obtain more reliable information about the sacrum dose.
Type of Study: Original Article |
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