1- , smmirrokni@live.com
Abstract: (5479 Views)
Background: Botulinum
toxin (Dysport) is a powerful semi-biological toxin. It has proved to be a
remarkable therapeutic agent for treatment of benign anal disorders. Different
results have been achieved from injection of botulinum toxin in order to
treatment of anal fissure since 1993. The aim of this study was to evaluate the efficacy of
botulinum toxin injection in the treatment of chronic anal fissure Comparing
with lateral internal anal sphincterotomy (LIS).
Methods: 36 patients
entered into two groups, Dysport injection and Lateral Internal Sphincterotomy,
randomly. Dysport group were treated by injection of 50 units of
botulinum toxin, 25 units of drugs in each side, and LIS was done in
surgery group by open method in left side. Pain, recovery and incontinency were
compared between two groups during six months of follow up.
Results: Based on this study,
treatment of anal fissure does not affected by age and gender. Regarding to
location of fissure, there was no difference between two different genders. Mean of age and ratio of gender were similar in both
groups. The severity of pain in surgery group was lower than Dysport group six
months after treatment (0.4±0.7 and 3.2±2.6 respectively, p<0.001). Recovery ratio in surgery group was higher than Dysport after six
months (95% Vs. 44.4% p<0.001). Gas or fecal incontinency did not reported after
six months in both groups.
Conclusion: Botulinum toxin is not efficacious in patients
with chronic anal fissure, comparing with LIS. More future studies are necessary for final judgement.