Volume 71, Issue 10 (January 2014)
Tehran Univ Med J 2014, 71(10): 660-664 |
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Sohrabvand F, Shariat M, Farahvash M J, Haghollahi F, Khosravi M, Maasomi M, et al . Serological study of Helicobacter pylori infection in patients with Polycystic Ovary Syndrome. Tehran Univ Med J 2014; 71 (10) :660-664
URL: http://tumj.tums.ac.ir/article-1-5735-en.html
URL: http://tumj.tums.ac.ir/article-1-5735-en.html
Farnaz Sohrabvand * 
1, Mamak Shariat2 , Mohammad Jafar Farahvash3 , Fedyeh Haghollahi4 , Mahnoosh Khosravi5 , Masoomeh Maasomi4 , Maryam Bagheri4 , Alireza Abdollahi6 , Akram Sarbiyaie6 , Fariba Bashari4
1, Mamak Shariat2 , Mohammad Jafar Farahvash3 , Fedyeh Haghollahi4 , Mahnoosh Khosravi5 , Masoomeh Maasomi4 , Maryam Bagheri4 , Alireza Abdollahi6 , Akram Sarbiyaie6 , Fariba Bashari4
1- Department of Obstetrics Gynecology & Infertility, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. , fsohrabvand@yahoo.com
2- Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Gastroenterology Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
4- Vali-e-Asr Reproductive Health Research Center Tehran University of Medical Sciences, Tehran, Iran.
5- Statistics & Ethics Committee, Ministry of Health Technology Research Deputy Tehran, Iran.
6- Vali-e-Asr Hospital Laboratory, Tehran University of Medical Sciences, Tehran, Iran.
2- Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Gastroenterology Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
4- Vali-e-Asr Reproductive Health Research Center Tehran University of Medical Sciences, Tehran, Iran.
5- Statistics & Ethics Committee, Ministry of Health Technology Research Deputy Tehran, Iran.
6- Vali-e-Asr Hospital Laboratory, Tehran University of Medical Sciences, Tehran, Iran.
Abstract: (13903 Views)
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Chronic infections have been mentioned as one of the different etiologic factors related to PCOS. Due to the high prevalence of Helicobacter pylori infection especially in developing countries, its probable role in the pathogenesis of PCOS and the limited information available in this area, serologic study of H.Pylori infection in patients with PCOS, was performed.
Methods: This research was performed as a case control study from Dec 2010 until May 2012 in 82 patients (and their spouses) with polycystic ovary syndrome (case group) and 82 non PCOS patients (control group) with an age range of 20-40 referred to Vali-e-Asr Hospital infertility clinic. Both groups and their husbands filled a questionnaire and were examined by testing their serum H.Pylori IgG and IgA antibody levels. Statistical testing and analysis was performed by t-student and λ2 tests.
Results: Mean age of the women and men and also other demographic characteristics except their profession showed no significant difference (P>0.05) in the two groups (PCOS and non PCOS). H.Pylori antibody IgG serum level was positive in 78% and 76.5% and H.Pylori antibody IgA level in 30.5% and 37% of PCOS versus non PCOS patients respectively which showed no statistically significant difference (P>0.05). There was also no significant difference between the H.Pylori antibodies levels in the spouses in the two groups (P>0.05).
Conclusion: This study showed no significant difference in serologic examination re-sults in PCOS versus non PCOS patients. The finding of high prevalence of H.Pylori IgG and IgA positive levels in both PCOS and non PCOS patients can be probably re-lated to the high prevalence of H.Pylori infection or exposure in Iranian population and therefore suggest an issue for further investigation.
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