Volume 73, Issue 9 (December 2015)                   Tehran Univ Med J 2015, 73(9): 646-652 | Back to browse issues page

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Abbas Zadeh A, Mahzooni T, Emami S A, Akbari H, Fatemi M J, Saberi M, et al . The effect of Coriander cream on healing of superficial second degree burn wound. Tehran Univ Med J. 2015; 73 (9) :646-652
URL: http://tumj.tums.ac.ir/article-1-7027-en.html
1- Department of Plastic and Reconstructive surgery, Lorestan University of Medical Sciences, Khorram Abad, Iran.
2- Department of Pharmacology, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Plastic and Reconstructive Surgery, Moheb Hazrat Fatemeh Hospital, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Burn Research Center and Department of Plastic and Reconstructive Surgery, Iran University of Medical Sciences, Tehran, Iran. , mjfatemi41@gmail.com
5- Department of Community Medicine, Quran and Hadith Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
6- Department of Nursing, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
7- Department of Occupational Therapy, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abstract:   (7264 Views)

Background: Coriander with the binominal name of Corianda Sativum, is one of the oldest medicinal plants ever known to man. Anti-inflammatory, anti-microbial, and anti-fungal effects of its oil has been mentioned in numerous studies. This study examines the impact of coriander cream on wound healing of the second-degree singe burn.

Methods: In this experimental study which was performed in the animal lab of the Hazrat Fatemeh Hospital in Tehran, 48 adult male rats with an approximate weight of 250-300 grams, with deep burns of 2 cm 4×2 dimensions were prepared and divided into 4 groups of 12. We used silver sulfadiazine cream, alpha ointment, coriander cream and vaseline gauze (control group) dressings in burn wound of the groups 1 to 4 respectively. At the end of the study (30 days), rats were euthanized with a high dose of thiopental and the wounds were evaluated on days 10 and 17 with a punch biopsy. Samples were fixed with 10% formalin on histopathology slide using haematoxylin and eosin (H&E) staining (to assess and determine the presence of inflammatory cells). The amount of fibrin and collagen at the site were evaluated using a software program ImageJ, version 1.45 (National Institutes of Health, Bethesda, Maryland, USA).

Results: The mean of wound surface area in the first photography was no significant (P= 0. 135). The rate of wound healing in alpha ointment and coriander cream had better outcomes than either of the other two groups (P= 0.000). The healing of the wound in silver sulfadiazine group was significantly less than other groups. Pathology results showed a statistically significant difference between the four groups (coriander, alpha, SSD and control), based on the Kruskal-Wallis test. These relate to (1) polymorphonuclear in the first (P= 0.032) and the second series (P= 0.003), (2) Angiogenesis in the second series (P= 0.004). (3) Fibrosis in the first series (P= 0.024) and the second series (P= 0.000).

Conclusion: The results of this study showed that wound healing improvement in coriander cream group was better than the control group and silver sulfadiazine group and similar to alpha ointment group.

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