Volume 62, Issue 2 (12 2004)                   Tehran Univ Med J 2004, 62(2): 108-114 | Back to browse issues page

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Mahjoob F, Yavari M, Jahanzad I. The Study Of Relationship Between PCNA And Ki67 (Cell Proliferation Markers) And Histologic Parts Of Wilms’s Tumor. Tehran Univ Med J 2004; 62 (2) :108-114
URL: http://tumj.tums.ac.ir/article-1-1127-en.html
Abstract:   (5698 Views)

Background: Wilm’s tumor is the most frequent primary renal neoplasma in pediatric age group. Classically it is composed of three histologic parts: Blastemal, Epithelial and stromal. Different factors are implicated as prognostic determinants. Nowadays special attention is paid to proliferation markers for determining the biologic behavior of tumors. In this study we tried to ascertain the proliferative index of 22 cases of Wilm’s tumor in our center who have had rather good follow up (at least two years).

Materials and Methods: After reviewing the H and E slides, we stained sections with PCNA and ki67 and scanned them by image cytomertry. Then the proliferative indices for each histological part was determined.

Results: We resuted that proliferative indices of blastemal and epithelial parts have significant (P< 0.0002) difference (increment) from that of stromal part. Also the patients were divided into those with recurrence (within two ys of primary surgery) and recurrence. The profileration indices of PCNA for those recurring tumors was significantly higher (PCNA= 22.3%) (P= 0.0015).

Conclusion: Finally we concluded that using proliferative markers in Wilm’s tumor is useful as an effective prognostic factor.

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