Volume 82, Issue 4 (July 2024)
Tehran Univ Med J 2024, 82(4): 323-328 |
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Qaraei N, Jafari M A, Jafari M, Karami Robati F, Parvaresh S. Comparison of serum vitamin D levels in children with nephrolithiasis and healthy children: a cross-sectional study. Tehran Univ Med J 2024; 82 (4) :323-328
URL: http://tumj.tums.ac.ir/article-1-13130-en.html
URL: http://tumj.tums.ac.ir/article-1-13130-en.html
Navid Qaraei1 
, Mohammad Ali Jafari2 , Maedeh Jafari3 , Fatemeh Karami Robati4 , Saeedeh Parvaresh * 5
, Mohammad Ali Jafari2 , Maedeh Jafari3 , Fatemeh Karami Robati4 , Saeedeh Parvaresh * 5
1- Department of Otorhinolaryngology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
2- Department of Basic Veterinary Sciences, Science and Research Unit, Islamic Azad University, Tehran, Iran.
3- Department of Pediatrics, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
4- Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
5- Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. ,S.parvaresh@Kmu.ac.ir
2- Department of Basic Veterinary Sciences, Science and Research Unit, Islamic Azad University, Tehran, Iran.
3- Department of Pediatrics, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
4- Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
5- Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. ,
Abstract: (89 Views)
Background: Nephrolithiasis is one of the oldest known systemic diseases of kidney and urinary tract in children. This study aimed to compare the serum level of vitamin D in children with nephrolithiasis and healthy children.
Methods: The present descriptive-cross-sectional study was conducted from October 2017 to September 2019. 74 children with kidney stones and 63 healthy children referring to Afzalipour Hospital in Kerman were selected by simple sampling method. Healthy children who were considered as the control group were matched with the case group in terms of age and gender. All patients underwent kidney and urinary tract ultrasound. The diagnosis of kidney stones was based on the radiologist's opinion. Demographic characteristics of patients (age and sex) were recorded. Patients' blood tests were checked for vitamin D and calcium. Descriptive and analytical methods and SPSS software version 21 were used to analyze the data.
Methods: The present descriptive-cross-sectional study was conducted from October 2017 to September 2019. 74 children with kidney stones and 63 healthy children referring to Afzalipour Hospital in Kerman were selected by simple sampling method. Healthy children who were considered as the control group were matched with the case group in terms of age and gender. All patients underwent kidney and urinary tract ultrasound. The diagnosis of kidney stones was based on the radiologist's opinion. Demographic characteristics of patients (age and sex) were recorded. Patients' blood tests were checked for vitamin D and calcium. Descriptive and analytical methods and SPSS software version 21 were used to analyze the data.
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Results: The average age of children with kidney stones and healthy children was 5.41±1.8 and 10.06±0.41 years old, respectively (P=0.971). The most number of patients were boys (58.1%). 29.7% of patients and 15.9% of healthy children had a family history of kidney stones (P=0.056). 71.6% of patients had unilateral kidney stones and 28% had bilateral kidney stones. The mean serum level of vitamin D was higher in healthy children (P=0.021). The average calcium was higher in children with kidney stones (P=0.001). The average calcium was higher in children with kidney stones who had a family history of kidney stones (P=0.018). Average calcium was higher in children with bilateral kidney stones (11.4±1.1) (P=0.033). The mean calcium was higher in children with kidney stones with vitamin D deficiency (P=0.001) and sufficient vitamin D levels (P=0.037).
Conclusion: The average level of vitamin D serum in healthy children was significantly higher than that of children with kidney stones, and the average level of calcium in children with kidney stones was significantly higher than that of healthy children. Larger studies with more patients are needed to investigate these relationships. |
Type of Study: Original Article |
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