Volume 82, Issue 6 (September 2024)
Tehran Univ Med J 2024, 82(6): 452-458 |
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Kalani N, Taheri L, Eftekharian F, Talebi A, Haghbeen M. Investigating the role of vitamin D deficiency as a risk factor and prognosis of breast cancer: a case-control study. Tehran Univ Med J 2024; 82 (6) :452-458
URL: http://tumj.tums.ac.ir/article-1-13180-en.html
URL: http://tumj.tums.ac.ir/article-1-13180-en.html
1- Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.
2- Department of Surgery, Women's Health and Diseases Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
3- Department of Internal Medicine, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
4- Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.
5- Department of Surgery, Women's Health and Diseases Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran. ,drhaghbeenoncosurg@gmail.com
2- Department of Surgery, Women's Health and Diseases Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
3- Department of Internal Medicine, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
4- Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.
5- Department of Surgery, Women's Health and Diseases Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran. ,
Abstract: (23 Views)
Background: Breast cancer is the most common cancer diagnosed in women. Epidemiological studies have led to the hypothesis that vitamin D may reduce the risk of breast cancer. This study aimed to investigate the association between vitamin D deficiency and breast cancer.
Methods: This case-control study was conducted on 59 patients referred to Khatam Al-Anbia Comprehensive Cancer Clinic in Jahrom city between May 2021 and March 2022. Thirty patients with pathologically confirmed ductal or lobular breast cancer in situ or invasive in one or both breasts, with no previous history of the disease and within two months of their breast cancer diagnosis, were considered as the case group. Thirty women without breast cancer who had been referred for breast screening examination were considered as the control group. Both groups were matched for demographic characteristics and age. The data collection tools in this study included demographic information and clinical history of the patients and serum vitamin D levels. Data analysis was performed using SPSS software, version 21 (IBM SPSS, Armonk, NY, USA) and descriptive statistics (mean, percentage, and standard deviation) and inferential statistical tests (logistic regression, Kolmogorov-Smirnov). The significance level was considered to be P<0.05.
Methods: This case-control study was conducted on 59 patients referred to Khatam Al-Anbia Comprehensive Cancer Clinic in Jahrom city between May 2021 and March 2022. Thirty patients with pathologically confirmed ductal or lobular breast cancer in situ or invasive in one or both breasts, with no previous history of the disease and within two months of their breast cancer diagnosis, were considered as the case group. Thirty women without breast cancer who had been referred for breast screening examination were considered as the control group. Both groups were matched for demographic characteristics and age. The data collection tools in this study included demographic information and clinical history of the patients and serum vitamin D levels. Data analysis was performed using SPSS software, version 21 (IBM SPSS, Armonk, NY, USA) and descriptive statistics (mean, percentage, and standard deviation) and inferential statistical tests (logistic regression, Kolmogorov-Smirnov). The significance level was considered to be P<0.05.
| Results: The mean age of the patients participating in the case group was 52.17±10.6 and in the control group was 51.24±9.7. There was no statistically significant difference in age (P=0.654). There was also no significant difference between the two groups in terms of body mass index and different body index classifications, menopause age, and age of onset of menstruation. The number of months of breastfeeding in the control group was significantly higher than the case group (P=0.001). The results of logistic regression showed that, on the other hand, there was no significant relationship between the type of pathology of the disease and serum vitamin D levels. Conclusion: The results of the present study showed that vitamin D deficiency can be a poor prognostic factor in the course of breast cancer. |
Type of Study: Original Article |
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