Volume 82, Issue 6 (September 2024)
Tehran Univ Med J 2024, 82(6): 466-475 |
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Rabbani M H, Farzanegi P, Azarbayjani M A. Investigating the effect of aerobic training and Ursolic acid consumption on the expression of some genes of the sarcopenia and osteoporosis signaling pathways in type 2 diabetic model aged rats. Tehran Univ Med J 2024; 82 (6) :466-475
URL: http://tumj.tums.ac.ir/article-1-13187-en.html
URL: http://tumj.tums.ac.ir/article-1-13187-en.html
1- Department of Sport Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
2- Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
2- Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
Abstract: (62 Views)
Background: Aerobic exercise and the consumption of certain supplements, such as ursolic acid, may reduce sarcopenia and osteoporosis by activating or inhibiting specific genes and signaling pathways. This study aimed to investigate the effects of aerobic exercise and ursolic acid supplementation on the expression of genes related to inflammatory and autophagy pathways in type 2 diabetes.
Methods: This experimental study was conducted from May 2023 to October 2023 at Islamic Azad University, Sari Branch. A total of 30 male Wistar rats (12 months old, mean weight 390 g) were randomly assigned to five groups: 1) healthy (normal), 2) diabetic, 3) diabetic+exercise, 4) diabetic+supplement, 5) diabetic+exercise+ supplement. Diabetes was induced via intraperitoneal injection of streptozotocin (50 mg/kg body weight). The aerobic exercise protocol was performed five days a week for eight weeks. The supplement groups received a daily intraperitoneal injection of ursolic acid (250 mg/kg body weight).
Methods: This experimental study was conducted from May 2023 to October 2023 at Islamic Azad University, Sari Branch. A total of 30 male Wistar rats (12 months old, mean weight 390 g) were randomly assigned to five groups: 1) healthy (normal), 2) diabetic, 3) diabetic+exercise, 4) diabetic+supplement, 5) diabetic+exercise+ supplement. Diabetes was induced via intraperitoneal injection of streptozotocin (50 mg/kg body weight). The aerobic exercise protocol was performed five days a week for eight weeks. The supplement groups received a daily intraperitoneal injection of ursolic acid (250 mg/kg body weight).
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Results: Data analysis showed that there was a statistically significant difference between the groups in the expression levels of LC3, Becline-1, TNFα, IL-1β Akt, and FOXO3 genes (P=0.000). The results of the post hoc test also showed that the expression level of LC3, Becline-1, TNFα, IL-1β genes in the model group increased significantly compared to the normal group (P=0.000). A significant difference was observed between intervention groups (P<0.05). The results of the follow-up test also showed that the level of expression of Akt genes in the model group was significantly decreased compared to the normal group (P=0.000). No significant difference was observed between intervention groups (P<0.05).
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Conclusion: The results of the study showed that regular aerobic training and Ursolic acid consumption can affect inflammatory and autophagy pathways. These effects reduce cell atrophy through changes in some biological signals and help improve muscle function in type 2 diabetes. Therefore, aerobic training and Ursolic acid consumption can serve as an effective strategy for improving metabolic status and preventing cellular damage in this patient population.
Type of Study: Original Article |
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