Volume 82, Issue 8 (November 2024)
Tehran Univ Med J 2024, 82(8): 598-610 |
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Gharib A, Yazdanparast S, Mohammadi Torbati P. Evaluation of urothelial carcinoma variants and its
relationship with invasion of muscularis propria. Tehran Univ Med J 2024; 82 (8) :598-610
URL: http://tumj.tums.ac.ir/article-1-13303-en.html
URL: http://tumj.tums.ac.ir/article-1-13303-en.html
Evaluation of urothelial carcinoma variants and its
relationship with invasion of muscularis propria
1- Department of Pathology, Clinical Research Development Center, Shahid Modarres Educational Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Pathology, Clinical Research Development Center, Shahid Modarres Educational Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ,saharyazdanparast88@gmail.com
3- Department of Pathology, Labbafinezhad Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Pathology, Clinical Research Development Center, Shahid Modarres Educational Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ,
3- Department of Pathology, Labbafinezhad Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract: (859 Views)
Background: It is necessary to determine the morphological type of invasive urothelial carcinoma and their invasive behavior to surrounding tissues. What we will discuss in the present study will be the examination of the types of urothelial carcinoma variants and its relationship with the invasion of the muscularis propria.
Methods: In this descriptive study, the study population included: all patients with ureteral carcinoma and other bladder malignancies with a history of hospitalization in Labafinezhad and Modares hospitals from April 2019 to March 2023. To collect data, after approval by the university ethics committee, files of patients with ureteral carcinoma and other bladder malignancies were extracted from the pathology department archives of Labafinezhad and Modares hospitals. Background information, clinical characteristics, laboratory and pathological data of the patients were collected and recorded by reviewing their archive files. Divergent differentiation and morphology of various variants of carcinomas included in the study were evaluated and the percentage of each was determined. Also, cases with muscularis propria invasion were identified and the frequencies of each type of invasion in different variants were determined.
Methods: In this descriptive study, the study population included: all patients with ureteral carcinoma and other bladder malignancies with a history of hospitalization in Labafinezhad and Modares hospitals from April 2019 to March 2023. To collect data, after approval by the university ethics committee, files of patients with ureteral carcinoma and other bladder malignancies were extracted from the pathology department archives of Labafinezhad and Modares hospitals. Background information, clinical characteristics, laboratory and pathological data of the patients were collected and recorded by reviewing their archive files. Divergent differentiation and morphology of various variants of carcinomas included in the study were evaluated and the percentage of each was determined. Also, cases with muscularis propria invasion were identified and the frequencies of each type of invasion in different variants were determined.
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Results: A total of 1243 patients participated in this study. The mean and standard deviation of the age of the patients were 65.2 and 11.2 years, respectively. 152 people (12.3%) were women and 1091 people (87.7%) were men. Patients with PT1 stage constitute more than 50% of cases. PT4 stage patients account for only 2.7% of cases. The highest frequency is in low grade papillary urothelial carcinoma.
Conclusion: The present study showed that about 27% of patients had Muscularis Propria invasion. In the high grade invasive urothelial carcinoma variant compared to other variants, muscularis propria invasion has been observed in a higher proportion of patients, and in the low grade papillary urothelial carcinoma variant, the lowest proportion of muscularis propria invasion has been seen. |
Type of Study: Original Article |
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