Volume 83, Issue 9 (December 2025)
Tehran Univ Med J. 2025, 83(9): 690-694 |
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Karampour Firoozi A, Abbaszadeh H, Soltani R, Aghajanpour F, Afshar A, Haghighi Morad M. Bilateral thalamic glioma: a case report. Tehran Univ Med J. 2025; 83 (9) :690-694
URL: http://tumj.tums.ac.ir/article-1-13866-en.html
URL: http://tumj.tums.ac.ir/article-1-13866-en.html
Ali Karampour Firoozi1, Hojjat-Allah Abbaszadeh2, Reza Soltani3, Fakhroddin Aghajanpour3, Azar Afshar3, Maryam Haghighi Morad *4
1- Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.| Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Radiology Department, Loghman Hakim Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.| Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3- Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Radiology Department, Loghman Hakim Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract: (108 Views)
Background: Primary thalamic tumors account for 0.8-1.5% of Central nervous system (CNS) tumors and approximately 25% of these are seen in patients younger than 15 years. These tumors are low-grade unilateral astrocytomas. Bilateral thalamic gliomas (BTGs) are rare and have a poor prognosis. These benign tumors have a lower prevalence than unilateral thalamic gliomas. These gliomas are a large tumor and are seen symmetrically in both thalami. Young children with BTGs often exhibit signs of increased intracranial pressure and motor disorders, while older children and adults generally experience cognitive disorders alongside behavioral changes, such as personality shifts or dementia. Given that these tumors are uncommon in young children, reporting them is crucial for guiding neurosurgeons in treatment.
Case Presentation: The patient was a 16-year-old male who came in with morning headaches and nausea, having shown no improvement with nonsteroidal anti-inflammatory drugs (NSAIDs). Recently complaint of dementia and has no movement disorders. The motor examination has shown force limbs 5/5 that shows the normal function of limbs and no family history of cancer was recorded in the patient's file. Brain MRI demonstrates changes in signals and bilateral volume increase of the thalamus, which also has been involved the brainstem. These findings are favor of BTG. BTG, predominant on the right thalamus, shows a high signal on T2 and FLAIR. This is an important mass effect on adjacent structures without surrounding perilesional oedema, causing mild shifting of midline structures to the left side. After the intravenous administration of Gadolinium chelate, no enhancement was observed. This tumor is probably related to low-grade gliomas.
Conclusion: Our case study results indicate that BTG tumors are rare and likely present distinct signs in patients. These clinical signs differ from those of unilateral thalamic gliomas and are limited during early life. The treatment process is also different for different people, depending on the clinical symptoms and physical condition of the patient, and sometimes surgery is not required
Case Presentation: The patient was a 16-year-old male who came in with morning headaches and nausea, having shown no improvement with nonsteroidal anti-inflammatory drugs (NSAIDs). Recently complaint of dementia and has no movement disorders. The motor examination has shown force limbs 5/5 that shows the normal function of limbs and no family history of cancer was recorded in the patient's file. Brain MRI demonstrates changes in signals and bilateral volume increase of the thalamus, which also has been involved the brainstem. These findings are favor of BTG. BTG, predominant on the right thalamus, shows a high signal on T2 and FLAIR. This is an important mass effect on adjacent structures without surrounding perilesional oedema, causing mild shifting of midline structures to the left side. After the intravenous administration of Gadolinium chelate, no enhancement was observed. This tumor is probably related to low-grade gliomas.
Conclusion: Our case study results indicate that BTG tumors are rare and likely present distinct signs in patients. These clinical signs differ from those of unilateral thalamic gliomas and are limited during early life. The treatment process is also different for different people, depending on the clinical symptoms and physical condition of the patient, and sometimes surgery is not required
Type of Study: Case Report |
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