Isolation of HDL2 and HDL3 assessment of concentration of cholesterol

Dusti , M

Volume 55, Issue 6 (1 1997) Tehran Univ Med J 1997, 55(6): 7-12 | Back to browse issues page

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Dusti M. Isolation of HDL2 and HDL3 assessment of concentration of cholesterol. Tehran Univ Med J 1997; 55 (6) :7-12
URL: http://tumj.tums.ac.ir/article-1-1606-en.html

Isolation of HDL2 and HDL3 assessment of concentration of cholesterol

M Dusti ^*

Abstract: (5586 Views)

The major Lipoprotein classes are heterogenous. Human serum High-Density-Lipoproteins (HDL) are separated into two major subfractions (HDL2, d=1.063-1.125 g/ml, HDL3, d=1.125-1.210 g/ml) by a simple double precipitation method. There was a strong inverse relation between HDL-Cholesterol (HDL-C) and subfractions HDL2-C and HDL3-C with atherosclerosis. This study demonstrated that HDL-C (P<0.001) and both HDL2-C (P<0.001) and HDL3-C (P<0.01) levels are significantly lower (HDL-C=-35%, HDL2-C=-52%, and HDL3-C=-26%) in the atherosclerosis patients (Coronary-Heart-Disease) than normal subjects. This data supports the proposal that the latter surfation is the major contributor to the anti atherogenic role of serum HDL-C, HDL2-C and HDL3-C.

Keywords: HDL

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