Volume 55, Issue 5 (1 1997)
Tehran Univ Med J 1997, 55(5): 5-10 |
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Alaiy H, Hajiamiri R. Comparison of effects of Idazoxan and 5-HTP on anxiety with Chlordiazepoxide. Tehran Univ Med J 1997; 55 (5) :5-10
URL: http://tumj.tums.ac.ir/article-1-1626-en.html
URL: http://tumj.tums.ac.ir/article-1-1626-en.html
Abstract: (8361 Views)
We studied the effect of the selective alha-2 adrenoceptor blocker idazoxan and precursor serotonin (5-HTP) on anxiety-related behavior in rats. The conflict drinking test, and evaluator plus-maze were used as model. Idazoxan (2 mg/kg) showed an anticonflict effect, having doses dependently increased the number of punished lickes. 5-HTP showed that anxiolytic-like effect in both models. This drug reversed action and produced anxiogenic-like effect at high doses. In contrast, arecholine which is a cholinergic muscarinic agonist drug, produced anxiogenic-like behavior. At 2 mg/kg increased number of entrance (OE) and using time (OT) in open arms in montgomery's test. Anxiolytic-like effect of this drug was less than of chlordizepoxide. These results showed that increase release of noradrenaline in synaptic nerve terminals of neurons produced anxiety-related behavior. While high release of serotonin in this area reduced behaviors disorder in rats.
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