Volume 55, Issue 3 And 4 (30 1997)                   Tehran Univ Med J 1997, 55(3 And 4): 1-6 | Back to browse issues page

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Sadeghipur Rudsari. Evaluation of contraceptive effects of 2,4 diamino- 5 (3,4 dichloro phenyl) 6-alcheloxymethyl pyrimidine on male rats. Tehran Univ Med J. 1997; 55 (3 and 4) :1-6
URL: http://tumj.tums.ac.ir/article-1-1642-en.html
Abstract:   (4929 Views)
The discovery of antifertility activity of gossypol led the scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptive. It is obvious that without the contribution and sense of responsibility in men, the population control programs and family planning will have no considerable success. In the present study, I have tried to evaluate two newly synthesized analog of diaminopyrimidines compounds with the chemical name of 2,4-diamino-5 (3,4-dichlorophenyl) 6-alcheloxymethylpyrimidine (ethyoxy and isobothyloxy) on male rats. This study indicates that this compounds without any toxic effects, significantly decrease the serum testosterone, sperm mortility (SM), percent of viable sperms, daily sperm production (DSP), epididimal sperm reserve (ESR) and fertility rats
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