Volume 53, Issue 1 (30 1995)                   Tehran Univ Med J 1995, 53(1): 31-35 | Back to browse issues page

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Mohyeddin M, Khosravi F, Nikbin B. Distribution of HLA antigents in Turkman race. Tehran Univ Med J. 1995; 53 (1) :31-35
URL: http://tumj.tums.ac.ir/article-1-1702-en.html
Abstract:   (4477 Views)
The Turkmans are one of the Iranian ethnic population. HLA typing (class I and II) was performed in this population. The data obtained from this study was compared with different populations of the world. We observed that the Turkman population is most similar to the Northern chinese and Uigur population. The distributions of HLA antigens in Turkmans are somewhat between Iranian population, Northern chinese and Uigur population. Natural selection and gene alteration select the people who could better adopt themselves with new conditions. Investigation of Turkman's HLA in comparison with Iranian's HLA reveals more details in genetics of Behcet's disease. Behcet's disease is very rare in Turkmans (index 0.5) whereas its frequency is high in other Iranians and Northern chinese. Distribution of susceptible antigens like B5 is the same in Turkmans and Northern chinese (19.5%) but much higher in other Iranians, whereas B35 have almost the same distribution in Turkmans and Iranians (37% and 33% respectively). DQW1 and CW4 antigens which were suspected to have a negative association with Behcet's disease are the most frequent antigens in Turkmans.
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