Volume 67, Issue 6 (9-2009)
Tehran Univ Med J 2009, 67(6): 428-434 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rezaei J, Esfandiari K, Tavakoli H, Sadooghi M, Hasibi M, Behzadi M. Evaluation of mupirocin ointment in control of central venous catheter related infections: a randomized clinical trial. Tehran Univ Med J 2009; 67 (6) :428-434
URL: http://tumj.tums.ac.ir/article-1-5578-en.html
URL: http://tumj.tums.ac.ir/article-1-5578-en.html
Jalal Rezaei1 
, Khalil Esfandiari * 2, Hassan Tavakoli1 , Mahmood Sadooghi3 , Mehrdad Hasibi4 , Mehrdad Behzadi5
, Khalil Esfandiari * 2, Hassan Tavakoli1 , Mahmood Sadooghi3 , Mehrdad Hasibi4 , Mehrdad Behzadi5
1- Department of Surgery, Otorhinolaryngology Research Center, Amir-Alam Hospital
2- Department of Surgery, Otorhinolaryngology Research Center, Amir-Alam Hospital ,kesfand@gmail.com
3- Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Amir-Alam Hospital
4- Department of Infectious Disease, Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences
5- Department of Anesthesiology, Otorhinolaryngology Research Center, Amir-Alam Hospital
2- Department of Surgery, Otorhinolaryngology Research Center, Amir-Alam Hospital ,
3- Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Amir-Alam Hospital
4- Department of Infectious Disease, Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences
5- Department of Anesthesiology, Otorhinolaryngology Research Center, Amir-Alam Hospital
Abstract: (134607 Views)
Background: Central venous catheter (CVC) related infections are important complications of cathter application. This study assessed the usefulness of mupirocin in prevention and control of these infections.
Methods: In this randomized clinical trial, consecutive surgical patients requiring central venous catheter (for more than 2 days) in Amir-Alam Hospital from 2006-2008 were enrolled. Patients were divided in two groups in “case group” patients received topical mupirocin 2% every 48 hours at the time of insertion of catheter and dressing change and for “control group” mupirocin was not used. All of the patients received chlorhexidine and enoxoparin as complementary treatments. Two groups were comparable in regard of age, sex and risk factors.
Results: One hundred eighteen patients enrolled in the study (57 in case and 61 in control group) completed the study. 84 catheters in case group and 88 catheters in control group were inserted. The catheters in 90% of patients were inserted in jugular vein. At the end of study 29(16.8%) patients (16 in control versus 13 in case group) had catheter colonization (p=NS). Catheter related bloodstream infection was observed in 16(9.3%) patients (6 in case versus 10 in control group) (p=NS).Catheter related local infection was seen in 2(1.1%) patients of control versus none of mupirocin group. (p=NS).
Conclusions: Mupirocin was not effective to control and prevention of bacterial colonization and catheter related infection.
Methods: In this randomized clinical trial, consecutive surgical patients requiring central venous catheter (for more than 2 days) in Amir-Alam Hospital from 2006-2008 were enrolled. Patients were divided in two groups in “case group” patients received topical mupirocin 2% every 48 hours at the time of insertion of catheter and dressing change and for “control group” mupirocin was not used. All of the patients received chlorhexidine and enoxoparin as complementary treatments. Two groups were comparable in regard of age, sex and risk factors.
Results: One hundred eighteen patients enrolled in the study (57 in case and 61 in control group) completed the study. 84 catheters in case group and 88 catheters in control group were inserted. The catheters in 90% of patients were inserted in jugular vein. At the end of study 29(16.8%) patients (16 in control versus 13 in case group) had catheter colonization (p=NS). Catheter related bloodstream infection was observed in 16(9.3%) patients (6 in case versus 10 in control group) (p=NS).Catheter related local infection was seen in 2(1.1%) patients of control versus none of mupirocin group. (p=NS).
Conclusions: Mupirocin was not effective to control and prevention of bacterial colonization and catheter related infection.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
