The relationship between cerebrospinal fluid C-reactive protein and  neonatal meningitis

Khosravi , Nastaran; Khalesi , Nasrin; Noorbakhsh , Samileh; Javadinia , Shima; Asgarian , Ramin; Tabatabai , Azardokht

Volume 71, Issue 11 (February 2014) Tehran Univ Med J 2014, 71(11): 723-728 | Back to browse issues page

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Khosravi N, Khalesi N, Noorbakhsh S, Javadinia S, Asgarian R, Tabatabai A. The relationship between cerebrospinal fluid C-reactive protein and neonatal meningitis. Tehran Univ Med J 2014; 71 (11) :723-728
URL: http://tumj.tums.ac.ir/article-1-5788-en.html

The relationship between cerebrospinal fluid C-reactive protein and neonatal meningitis

Nastaran Khosravi¹

, Nasrin Khalesi²

, Samileh Noorbakhsh¹

, Shima Javadinia³

, Ramin Asgarian⁴

, Azardokht Tabatabai ^*

⁵

1- Department of Pediatric Infectious Diseases, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Neonatal Diseases, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Internal Medicine, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
4- Department of Community Medicine, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
5- Faculty Member, Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. , cpidir@gmail.com

Abstract: (9091 Views)

Background: Meningitis is one of the serious and dangerous infections in the infancy and childhood and rapid diagnosis of meningococcal disease is important, especially in infants. C-reactive protein (CRP) is a protein found in blood and is an acute phase protein. CRP sensitive reactive that used for diagnosis of infection. This study conducted to assessment of the relationship between cerebrospinal fluid C-reactive protein, and neonatal meningitis, as well as diagnostic value of test. Methods: Forty nine hospitalized infant that suspected to meningitis were enrolled in this analytic cross sectional research via non probable accessible sampling. 28 patients (52.7%) of all the patients were male and 21 patients (42.8%) were female. The average age of the patients was 22.6±11.88 days. Data from clinical examinations and laboratory tests entered in a questionnaire and all of samples divided in two bacterial (septic) and non-bactria (aseptic) meningitis group. All data including cerebrospinal fluid CRP of newborns were statistically analyzed. Results: In total, the mean and standard deviation of age was 22.6±11.88 days. 57.2% of infants were male and 42.8% were female. In total, 40.82% of infants were diagnosed with septic meningitis. There was no significant difference between septic and aseptic groups in terms of sex (P= 1.00) also in terms of age (P= 0.1). The mean and standard deviation of CRP level in septic meningitis group was 0.95±0.68 mg/L and in aseptic group was 0.16±0.36 mg/L. The CRP level difference in septic meningitis group compare with aseptic group was statistically significant (P<0.000). The finding showed that cut off point for CRP level as a diagnostic test was 0.17 mg/L, sensitivity was 95% and specificity was 86%. Conclusion: In the present study, newborns with septic meningitis had higher cerebrospinal fluid CRP level than newborns with aseptic meningitis, and CSF-CRP can be used in rapid diagnosis of septic and aseptic meningitis. Although this result has been seen in many studies, but more research is needed.

Keywords: C-reactive protein, cerebrospinal fluid, meningitis

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Type of Study: Original Article |