Volume 83, Issue 9 (December 2025)
Tehran Univ Med J. 2025, 83(9): 638-646 |
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Haddad M, Heydari A A, Honary H, Sheidae Mehne Z. Clinical characteristics, laboratory findings, and clinical outcomes in adult patients with Salmonella bacteremia: a 11-year study
in eastern Iran. Tehran Univ Med J. 2025; 83 (9) :638-646
URL: http://tumj.tums.ac.ir/article-1-13860-en.html
URL: http://tumj.tums.ac.ir/article-1-13860-en.html
1- Department of Infectious and Tropical Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: (107 Views)
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Background: Salmonella bacteremia is one of the invasive forms of salmonellosis, occurring more frequently in patients with underlying diseases and immunodeficiency, and it may be associated with significant mortality. The present study aimed to evaluate the demographic, clinical, and paraclinical characteristics, factors associated with clinical outcomes, and treatment outcomes of patients with Salmonella bacteremia.
Methods: In this retrospective cross-sectional study conducted in 2022, hospitalized adults (aged >18 years) with at least one positive blood culture for Salmonella between March 2011 and March 2022 were included. Demographic data, underlying diseases, clinical signs and symptoms, laboratory findings, therapeutic regimens, and clinical outcomes were extracted from the medical records. Cases with incomplete information were excluded from the study. Results: Thirty patients (mean age 41.13 ± 13.76 years; 53.3% male) were included. The most common comorbidities were malignancy, rheumatologic diseases, diabetes mellitus, and Human Immunodeficiency Virus infection, although 43.3% had no underlying disease. Fever, malaise, and diarrhea were the predominant manifestations. Elevated CRP (96.7%) and ESR (90%) were frequent, along with anemia (76.7%) and thrombocytopenia (56.7%). S. Typhi was the most common isolate (46.7%). Overall mortality was 16.7%. Empirical therapy mainly involved cephalosporins, while targeted treatment frequently shifted to fluoroquinolones. Initial aminoglycoside therapy and clinical features such as malignancy, arthralgia, back pain, constipation, and altered consciousness were associated with unfavourable outcomes. Conclusion: The findings of the study indicated that most patients with Salmonella bacteremia had underlying comorbidities. In adult patients with Salmonella bacteremia, clinical manifestations were mainly non-specific, and laboratory findings commonly included leukopenia, thrombocytopenia, and elevated liver enzymes. Despite a notable mortality rate, no strong independent predictor of death was identified. |
Type of Study: Original Article |
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