Volume 52, Issue 1 And 2 (30 1994)
Tehran Univ Med J 1994, 52(1 And 2): 16-21 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khonsari N, Jafari P, Dukan J. The effect of anti-depressant Amitriptyline on the immune system. Tehran Univ Med J 1994; 52 (1 and 2) :16-21
URL: http://tumj.tums.ac.ir/article-1-1723-en.html
URL: http://tumj.tums.ac.ir/article-1-1723-en.html
Abstract: (72525 Views)
We have studied the effect of amitriptyline, a tricyclic anti-depressant drug on several immune parameters of the Balb/c mice in order to evaluate its immunomodulatory effects. Results showed that amitriptyline will potentiates all of the immunocytes functions except for the production of PGE2 by LPS stimulated monocytes. We have also showed that amitriptyline can normalize the immunosuppressive effect of dexamethasone on mice (experimental stress). These results suggest that one of the mechanisms of action of the tricyclic anti-depressant drugs might be through the modulation of the immune system which has been suppressed by stress or distress
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
